Medication-Assisted Treatment

Understanding Ketamine Therapy Side Effects

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Learn ketamine therapy side effects, including common and serious risks, safe use guidance, informed recovery, and its role in mental health treatment.

Ketamine therapy is emerging as a promising option for individuals struggling with depression, PTSD, and other mental health challenges. While it offers hope when other treatments have failed, it’s essential to understand the potential ketamine therapy side effects before starting. 

If you or someone you care about is considering this treatment, knowing what to expect can help you make informed, confident decisions. At The Edge Treatment Center, we believe in supporting your recovery with clarity, compassion, and care, ensuring every step you take toward healing is backed by safe, personalized treatment.

What Is Ketamine Therapy?

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Ketamine therapy is a promising treatment approach for mental health and addiction issues when used safely under medical supervision.

Medical Use Vs. Recreational Use

Ketamine therapy involves the use of low, medically supervised doses of ketamine to treat conditions like depression, PTSD, anxiety, and addiction. 

Unlike recreational ketamine use—which can be dangerous, unpredictable, and illegal—therapeutic use is structured, controlled, and evidence-based. 

Recreational use often leads to misuse and adverse effects, while clinical ketamine therapy focuses on healing and recovery.

Ketamine-Assisted Psychotherapy (KAP) and Infusion Therapy

There are two primary forms of ketamine therapy: Ketamine-Assisted Psychotherapy (KAP) and IV or IM infusion therapy. In KAP, ketamine is combined with talk therapy during or after the session to deepen emotional processing. 

In infusion therapy, ketamine is administered in low doses through an IV or intramuscular injection under clinical supervision. Both approaches aim to improve mood, disrupt negative thought patterns, and support emotional breakthroughs.

Common and Short‑Term Side Effects

When beginning ketamine therapy, many people experience temporary, manageable side effects. These can include:

  • Dissociation (feeling detached from your body or surroundings)

  • Dizziness or lightheadedness

  • Nausea or vomiting

  • Headache

  • Blurred vision

  • Increased heart rate or blood pressure

These effects typically occur during or shortly after your session and wear off within a few hours. While they can be uncomfortable, they are not dangerous when monitored by medical professionals.

Physical Discomfort

Some individuals may also notice mild physical effects, such as fatigue or slight irritation at the injection site. These are usually short-lived and can be easily managed by our clinical team at The Edge Treatment Center.

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Less Common & Transient Psychological Effects

In some cases, patients may experience less common psychological effects, including:

  • Hallucinations or vivid dreams

  • Feelings of anxiety or panic during the session

  • Mild confusion or emotional intensity

These reactions are typically brief and tend to become less frequent with continued treatment. At The Edge, we provide a calm, supportive environment to help you feel safe during these moments.

Rare Mental Reactions

Rare psychological responses—such as mood swings, paranoia, or brief episodes of delirium—can occur but are uncommon in a structured clinical setting. Our trained staff is always present to support you and intervene if needed.

Rare but Serious & Long‑Term Risks

While rare, some serious side effects have been observed, especially with high doses or prolonged use outside medical supervision. These include:

  • Respiratory depression

  • Allergic reactions

  • Heart rhythm abnormalities (arrhythmia)

These risks are extremely uncommon when ketamine is used responsibly under medical supervision, as we do at The Edge Treatment Center.

Long-Term Physical Health Risks

With long-term or frequent use, patients may face risks such as:

  • Bladder inflammation (cystitis) or bladder damage

  • Liver toxicity in rare cases

We proactively minimize these risks through careful dosing and regular health evaluations.

Tolerance and Dependence

Although ketamine is not considered physically addictive like opioids, repeated use can lead to tolerance or psychological dependence. We address this by providing comprehensive mental health care alongside treatment, ensuring you're supported every step of the way.

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Risk Factors & Who Should Exercise Caution

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While ketamine therapy can offer powerful relief, certain medical and psychological conditions require special consideration before beginning treatment.

Medical Conditions That Require Extra Care

While ketamine therapy can be highly effective, it may not be suitable for everyone. Individuals with certain pre-existing medical conditions should be carefully evaluated before beginning treatment. These include:

  • Hypertension (high blood pressure)

  • Cardiovascular disease

  • Liver conditions

  • Bladder disorders or a history of urinary tract issues

At The Edge Treatment Center, we conduct a thorough medical assessment before starting ketamine therapy to ensure it’s safe for you. If any of these conditions are present, we may adjust the treatment plan or explore alternative options for your recovery.

Mental Health and Substance Use History

Ketamine therapy may also pose risks for those with a history of psychotic disorders, such as schizophrenia, as it can potentially trigger or worsen psychotic symptoms. 

Similarly, individuals with past or current substance misuse issues need careful screening, as ketamine does have the potential for psychological dependence if misused.

We take a personalized, cautious approach to treatment and work closely with you to make sure it supports—not complicates—your recovery.

Why Supervision Matters

Unsupervised or at-home use of ketamine—especially without professional guidance—can increase the risk of serious side effects, dependence, and medical complications. 

At The Edge Treatment Center, every ketamine therapy session is supervised by trained professionals in a controlled, therapeutic environment. This ensures your safety while maximizing the benefits of treatment.

Your well-being is always our priority, and that starts with making sure ketamine therapy is the right and safest option for your unique needs.

How We Keep You Safe at The Edge Treatment Center

At The Edge Treatment Center, we prioritize your safety through expert care, personalized treatment, and continuous support during every stage of ketamine therapy.

Comprehensive Initial Assessment

Your safety begins before your first session. We conduct a thorough initial assessment that includes your medical history, mental health background, current medications, and overall physical condition.

This helps us determine if ketamine therapy is appropriate for you and allows us to identify any conditions that may require extra precautions.

Professional Monitoring and Trained Staff

Each ketamine therapy session at The Edge Treatment Center is carefully monitored. Our team tracks your vital signs throughout the session, including blood pressure, heart rate, and oxygen levels. Our clinical staff is trained to manage any side effects or unexpected reactions, ensuring you feel secure and supported at every moment.

Tailored Dosing and Emergency Preparedness

There’s no one-size-fits-all approach here. We use personalized dosing based on your specific needs and how your body responds to treatment. If a medical issue arises, our facility is equipped with emergency protocols and trained staff to handle it immediately and effectively.

Integrated Therapy and Emotional Support

We don’t just administer ketamine—we combine it with emotional and psychological support. Many sessions include talk therapy or post-session integration to help you process your experience and gain deeper insight into your healing.

Ongoing Aftercare and Support

Your safety and progress remain our priority even after the session ends. We offer regular follow-up check-ins, monitor for side effects, and adjust your treatment plan as needed. Whether it’s your first session or your tenth, we walk with you every step of the way.

At The Edge Treatment Center, ketamine therapy is part of a larger journey toward lasting recovery, grounded in trust, compassion, and clinical excellence.

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Considering Ketamine Therapy? We’ll Help You Do It Safely

Ketamine therapy can be a powerful tool for healing when used with care, support, and medical oversight. Understanding ketamine therapy side effects is a crucial step in making informed decisions about your mental health and recovery journey. 

At The Edge Treatment Center, we’re here to guide you with expert care, personalized treatment plans, and compassionate support. Whether you’re exploring ketamine for the first time or have questions about safety, we’re ready to help you take the next step. Reach out today—we’re here to walk with you toward a better, healthier future.

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If you or a loved one is struggling with addiction, there is hope. Our team can guide you on your journey to recovery. Call us today.

Written by

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The Edge Treatment Center

Reviewed by

jeremy-arztJeremy Arzt

Chief Clinical Officer

Medication-Assisted Treatment

August 17, 2025

FAQ

Frequently Asked Questions

Common ketamine therapy side effects include dissociation, dizziness, nausea, headache, blurred vision, and increased heart rate. These symptoms are usually mild and short-lived when therapy is administered in a safe, medically supervised setting like The Edge Treatment Center.

Most ketamine therapy side effects occur during or shortly after the infusion and last about one to two hours. Some individuals may feel drowsy or foggy afterward, but these effects usually resolve by the end of the day with rest.

While ketamine isn’t considered physically addictive, repeated or unsupervised use can lead to psychological dependence. Receiving ketamine therapy under medical supervision helps minimize risks, including misuse and long-term side effects, ensuring the treatment supports your recovery without creating new challenges.

Ketamine therapy side effects can include increased heart rate and blood pressure. If you have hypertension or heart disease, a medical evaluation is required. At The Edge Treatment Center, we closely monitor your vitals to ensure safe, individualized treatment.

Bladder issues are a rare ketamine therapy side effect, but can occur with long-term or frequent use. Symptoms like discomfort or urinary changes should be reported promptly. We assess and monitor these concerns closely and adjust treatment to protect your health and comfort.